A. D. Jones

HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

The paper examines CD8+ T-cell exhaustion in HIV-1 controllers and finds that loss of control correlates with increased exhaustion markers, which can be reversed by immune checkpoint blockade.

Trading acyls and swapping sugars: metabolic innovations in Solanum trichomes

This study characterizes acylsugar diversity in Solanum species, identifying novel structures and enzymes involved in their biosynthesis.

Profiles of secoiridoids and alkaloids in tissue of susceptible and resistant green ash progeny reveal patterns of induced responses to emerald ash borer in Fraxinus pennsylvanica

The paper identifies chemotypes in green ash trees associated with defensive responses to emerald ash borer using metabolomics and phenotyping.

Bile acid-CoA:amino acid N-acyltransferase gene knockout alters early life development, the gut microbiome and reveals unusual bile acid conjugates in mice

This study shows that BAAT gene deletion in mice leads to altered bile acid conjugation, microbiome changes, and unusual bile acid conjugates, with potential rescue by other enzymes.

Identification of BAHD acyltransferases associated with acylinositol biosynthesis in Solanum quitoense (naranjilla)

The paper identifies three BAHD acyltransferases in Solanum quitoense involved in acylinositol biosynthesis and shows their in vitro products differ from in planta accumulation.

Natural Variation Meets Synthetic Biology: Promiscuous Trichome Expressed Acyltransferases from Nicotiana acuminata

The paper analyzes Nicotiana glandular trichome metabolites and BAHD acyltransferases to reveal diverse sucrose and glucose-based acylesters.

It happened again: convergent evolution of acylglucose specialized metabolism in black nightshade and wild tomato

The paper identifies convergent evolution of acylglucose metabolism in black nightshade and wild tomato through biochemical and genetic analysis of their biosynthetic pathways.

Lipid Bilayer Induces Contraction of the Denatured State Ensemble of a Helical-Bundle Membrane Protein

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

Switchgrass metabolomics reveals striking genotypic and developmental differences in specialized metabolic phenotypes

The paper uses metabolomics to show that switchgrass has diverse specialized metabolites varying by tissue and ecotype, with saponins being particularly abundant and ecotype-specific.

Metabolomic signatures of coral bleaching history

This study identifies metabolomic signatures linked to coral bleaching history, showing that prior bleaching affects both coral and algal biochemistry and influences thermal stress responses.

Solanaceae specialized metabolism in a non-model plant: trichome acylinositol biosynthesis

The paper identifies an enzyme involved in the final step of acylinositol biosynthesis in Solanum quitoense and shows evolutionary parallels with acylsucrose biosynthesis in Solanum lycopersicum.

Inhibition of microbial biofuel production in drought stressed switchgrass hydrolysate

This study investigates how drought stress in switchgrass affects biofuel production by inhibiting yeast fermentation due to the formation of toxic compounds during pretreatment.