D. Xie

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Sclerotic prostate cancer bone metastasis: woven bone lesions with a twist.

This study characterizes the bone structure of prostate cancer bone metastases using multiple techniques and identifies four phenotypes, including osteosclerotic lesions with abnormal woven bone-like features.

Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course

The paper quantifies age-related changes in regulatory and functional proteins in baboon adrenal zonae, finding decreased ZF function and less marked ZR function with age.

Frequency-dependent selection of neoantigens fosters tumor immune escape and predicts immunotherapy response

This study introduces negative frequency-dependent selection (NFDS) in tumors, showing it leads to immune evasion and poor response to immunotherapy, supported by whole-exome sequencing data.

LinguaPhylo: a probabilistic model specification language for reproducible phylogenetic analyses

This paper introduces a new model specification language, LPhy, for phylogenetic analyses to improve reproducibility and clarity in model descriptions.

Biosynthesis of plant papanridins -A group of novel oligomeric flavonoids

The paper reports a new polymerization pathway for novel oligomeric flavonoids called papanridins in plants and identifies a flavanol polymerase gene involved in their biosynthesis.

Seasonality but not photoperiodism affects susceptibility of the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) to pesticides

This study shows that seasonality, not photoperiodism, affects the susceptibility of spider mites to pesticides, with toxicity increasing in spring and summer and decreasing in winter.

Introduction of a condensed, reverse tricarboxylic acid cycle for additional CO2 fixation in plants

This paper introduces a synthetic carbon fixation cycle in plants that fixes CO2 without RuBisCO, showing increased photosynthetic capacity in transgenic Camelina sativa.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

This study identifies flavonols and dihydroflavonols as potential inhibitors of SARS-CoV-2 and HCoV-229E main protease activity and viral replication.

DAB2IP inhibits p53 ubiquitin-mediated degradation by competitively binding to GRP75 and suppresses tumor malignancy in colon cancer

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through its enhancer in breast cancer

This study shows YAP1 promotes breast cancer metastasis by enhancing TIAM1 expression through its enhancer, leading to increased RAC1 activity and invadopodia formation.

MMP12 Knockout Prevent Weight and Muscle Loss Induced by Cancer Cachexia

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

Correlation and co-localization of QTL for stomatal density and canopy temperature under drought stress in Setaria

The paper identifies QTLs for stomatal density and canopy temperature in Setaria under drought stress, showing their genetic correlation and potential for improving water use efficiency.

LINCS gene expression signatures analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1

This study identifies bosutinib as a radiosensitizer for breast cancer by targeting eIF4G1, enhancing radiation efficacy and reducing drug dosage.

Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway

This study shows decorin reduces high glucose-induced apoptosis and oxidative stress in lens epithelial cells by inhibiting the p22phox-p38 MAPK pathway.

Genome wide screen reveals a specific interaction between autosome and X that is essential for hybrid male sterility

The paper identifies multiple interacting genomic loci responsible for asymmetric hybrid male sterility and inviability between Caenorhabditis briggsae and C. nigoni.

BEAST 2.5: An Advanced Software Platform for Bayesian Evolutionary Analysis

The paper describes new developments in the BEAST 2.5 software platform for Bayesian evolutionary analysis, expanding joint inference over multiple data types and complex phylodynamics.

A GYS2/p53 negative feedback loop restricts tumor growth in HBV-related hepatocellular carcinoma

This paper identifies a GYS2/p53 negative feedback loop that suppresses tumor growth in HBV-related hepatocellular carcinoma by regulating glycogen metabolism and p53 activity.

Chemical genomic guided engineering of gamma-valerolactone tolerant yeast

The paper engineers a GVL-tolerant yeast strain by deleting PAD1 and FDC1, enhancing ergosterol content and improving fermentation in GVL-containing hydrolysates.

High-NA open-top selective-plane illumination microscopy for biological imaging

The paper develops a high-NA open-top SPIM system to improve compatibility with standard sample holders and demonstrates aberration correction for high-quality imaging.

Inhibition of microbial biofuel production in drought stressed switchgrass hydrolysate

This study investigates how drought stress in switchgrass affects biofuel production by inhibiting yeast fermentation due to the formation of toxic compounds during pretreatment.