CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.
S. Ackloo, C. H. Arrowsmith, F. Ban, C. J. Barden, H. Beck, J. Beranek, F. Berenger, A. Bolotokova, G. Bret, M. Breznik, E. Carosati, I. Chau, Y. Chen, A. Cherkasov, D. Della Corte, , Klebe
The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.
bioRxiv · Jul 18, 2024Biochemistry