Author

A. Bolotokova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Li· 4 shared M. Vedadi· 4 shared A. Khalili Yazdi· 3 shared K. Devkota· 3 shared P. Ghiabi· 3 shared S. Perveen· 3 shared T. Hajian· 3 shared I. Chau· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

F. Li

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Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 5, 2021

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

D. Dilworth, R. P. Hanley, R. Ferreira de Freitas…·M. Schapira

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

DOI 10.1101/2021.03.05.433782

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivFeb 19, 2021

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

K. Devkota, M. Schapira, S. Perveen…·M. Vedadi

This paper identifies SAM competitive inhibitors of SARS-CoV-2 nsp14 methyltransferase and characterizes their mechanism, guiding the development of selective bi-substrate inhibitors.

DOI 10.1177/24725552211026261

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivFeb 3, 2021

A high-throughput radioactivity-based assay for screening SARS-CoV-2 nsp10-nsp16 complex

A. Khalili Yazdi, F. Li, K. Devkota…·M. Vedadi

The paper develops a radioactivity-based high-throughput screening assay for the SARS-CoV-2 nsp10-nsp16 complex and optimizes it for HTS with a Z'-factor of 0.83.

DOI 10.1177/24725552211008863

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivOct 14, 2020

A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

S. Perveen, A. Khalili Yazdi, K. Devkota…·M. Vedadi

The paper develops a fluorescence polarization assay for screening RNA-competitive inhibitors of the SARS-CoV-2 nsp10-nsp16 complex, validated with 1124 compounds.

DOI 10.1177/2472555220985040

experimental assaydrug response / drug discovery

𝕏 PostBluesky