A. Ivanova

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization

This study measures the kinetics of SARS-CoV-2 virus-like particle internalization using live-cell microscopy, revealing key steps and their timing, and showing no effect of Omicron mutations or S protein cleavage site on internalization rates.

Concatenation of segmented viral genomes for reassortment analysis

The paper introduces a tool to concatenate segmented viral genomes for reassortment analysis, enabling the use of recombination detection methods on concatenated sequences.

FTSH3 facilitates complex I degradation through a direct interaction with the complex I subunit PSST

This study identifies FTSH3's role in complex I degradation by directly interacting with PSST, requiring its ATPase activity for proteolysis and turnover.

APOE Expression and Secretion are Modulated by Mitochondrial Dysfunction

This study shows mitochondrial dysfunction increases APOE expression and secretion in multiple cell types and models, linking mitochondrial health to Alzheimer's disease risk.

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

This study develops a transgenic pig model with SNAP-tagged insulin to investigate in vivo insulin secretory granule dynamics and turnover.

The root of the transmissible cancer: first description of a widespread Mytilus trossulus-derived cancer lineage in M. trossulus

The study identifies BTN2, a transmissible cancer lineage, in its original host M. trossulus in the Sea of Japan, suggesting it originated there and spread globally.