H. Beck

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

A probabilistic view of forbidden links: their prevalence and their consequences for the robustness of plant-hummingbird communities

The paper assesses the prevalence and impact of exploitation barriers on network robustness in plant-hummingbird communities using a Bayesian hierarchical model and interaction data.

replicAnt: A pipeline for generating annotatedimages of animals in complex environments usingUnreal Engine

replicAnt generates synthetic annotated images for animal behavior research, reducing hand-annotation needs and improving model robustness.

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

Mysterious disappearances of a large mammal in Neotropical forests

The paper documents periodic population cycles in white-lipped peccaries in Neotropical forests, showing synchronized disappearances and recovery phases over 20-30 years.

Extratubular polymerized uromodulin induces leukocyte recruitment and inflammation in vivo

This study shows extratubular polymerized uromodulin induces inflammation by recruiting leukocytes and affecting vascular permeability in vivo.