Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids
A. E. Aleshin, Y. Yao, A. Iftikar, A. A. Bobkov, J. Yu, G. Cadwell, M. Klein, C. Dong, L. A. Bankston, R. C. Liddington, W. Im, G. Powis, F. M. Marassi
This study determines the atomic structure of PLEKHA7's PH domain and reveals its multivalent interaction mechanism with membrane-bound PIPs, providing insights for inhibitor design.
bioRxiv · Nov 25, 2020Biochemistry