J. Yu

Discovery of Abundant Nano-scale Lymphatic-like Vessels in Brains

The paper discovers abundant nanoscale lymphatic-like vessels in brain parenchyma of mice and humans, suggesting a previously unrecognized system for metabolic waste clearance.

New structural features of the APC/C revealed by high resolution cryo-EM structures of apo-APC/C and the APC/C CDH1:EMI1 complex

This study uses cryo-EM to determine high-resolution structures of apo-APC/C and APC/C CDH1:EMI1, revealing new structural features and regulatory mechanisms.

Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HSNCC

This study shows that targeting the EphB4-ephrinB2 axis with engineered ligands reduces metastasis in HNSCC by modulating tumor microenvironment and immune responses.

Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.

Single-cell RNA Sequencing Reveals Methamphetamine Inhibits the Liver Immune Response with Involvement of the Dopamine D1 Receptor

This study uses single-cell RNA sequencing to show that chronic methamphetamine exposure alters liver immune cell composition and function, with involvement of the dopamine D1 receptor.

Phase-Separating Peptide Coacervates with Programmable Material Properties for Universal Intracellular Delivery of Macromolecules

This study manipulates phase-separating peptide sequences to control coacervate microdroplet properties and intracellular delivery kinetics of macromolecules.

Cancer Cachexia in STK11/LKB1-mutated NSCLC is Dependent on Tumor-secreted GDF15

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance

This study uses deep mutational scanning to analyze H5 hemagglutinin mutations and their impact on pandemic risk factors in influenza viruses.

Development of a humanized anti-FABP4 monoclonal antibody for treatment of breast cancer

This paper develops humanized anti-FABP4 monoclonal antibodies that inhibit breast cancer tumor growth and metastasis by targeting FABP4's role in lipid metabolism.

Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health

This study shows that ACC1 regulates adipose ILC2 differentiation and function in obesity, linking lipid metabolism to metabolic health.

Forage conservation is a neglected nitrous oxide source

This study investigates N2O emissions from forage conservation and finds it could be a significant source, with chlorate reducing emissions but other factors having no effect.

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent manner

This study identifies Exo70's role in herpesvirus secretory vesicle tethering and virion release via the exocyst complex, showing ES2 inhibits herpesvirus infection.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and Prolactin Gene Expression During Interval-Training Activities of Pituitary Cells

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

New insights into the mechanisms of plant isotope fractionation from combined analysis of intramolecular 13C and deuterium abundances in Pinus nigra tree-ring glucose

This paper analyzes intramolecular 13C and deuterium abundances in tree-ring glucose to understand isotope fractionation mechanisms and their climate responses.

A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 Receptor

This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.

The EGF/EGFR-YAP1/TEAD2 axis-mediated BRAF inhibitor vemurafenib resistance upregulates STIM1 in melanoma

This study identifies the EGF/EGFR-YAP1/TEAD2 axis as a mechanism by which vemurafenib resistance upregulates STIM1 in melanoma.

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy

This study uses targeted mRNA-LNPs to deliver IL-15 superagonists, improving anti-tumor efficacy while reducing toxicity compared to existing therapies.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1+ macrophages

This study identifies SPP1+ macrophages as early-stage biomarkers in idiopathic pulmonary fibrosis using single-cell transcriptomics and flow cytometry.

Highly Multiplexed Fluorescence Microscopy with Spectrally Tunable Semiconducting Polymer Dots

This paper introduces a method for highly multiplexed fluorescence microscopy using tunable semiconducting polymer dots, enabling imaging of up to 21 targets in a single round.

A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation.

This study identifies verteporfin as a potent CCL5/CCR5 axis antagonist that suppresses TNBC tumor growth and metastasis through CCR5-YAP1 regulation.

The heparin-binding domain of VEGF165 directly binds to integrin αvβ3 and plays a critical role in signaling.

This study identifies the heparin-binding domain of VEGF165 as critical for integrin αvβ3 binding and signaling, showing its role in mitogenic activity.