A. J. Radosevich

This paper demonstrates a high-throughput phenotypic screening method using IR-MALDESI mass spectrometry to identify glutaminase inhibitors and distinguish them from nuisance compounds.

This paper introduces OSPREY, an in-vitro flow-through system that quantifies precipitation of small molecule therapeutics in whole blood, validating its performance with microspheres and a tool compound.

This paper introduces a high-throughput label-free cellular pharmacodynamic assay using IR-MALDESI to identify glutaminase inhibitors and confirm hits with mass spectrometry-based assays.

This paper demonstrates the use of IR-MALDESI-MS for high throughput intact protein analysis in drug discovery, achieving faster sample rates than traditional ESI-MS methods.

This paper develops an ultrahigh-throughput IR-MALDESI mass spectrometry method capable of analyzing 22 samples per second with low carryover and high repeatability.