Pharmacology & ToxicologybioRxiv
In-vitro Modeling of Intravenous Drug Precipitation by the Optical Spatial Precipitation Analyzer (OSPREY)
A. J. Radosevich, R. L. Martin, W. R. Buck…·J. Y. Pan
This paper introduces OSPREY, an in-vitro flow-through system that quantifies precipitation of small molecule therapeutics in whole blood, validating its performance with microspheres and a tool compound.