Author

J. D. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Animal Behavior & Cognition· 1 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Assay:metabolomics· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1

Frequent Co-Authors

A. J. Radosevich· 4 shared F. Pu· 4 shared N. L. Elsen· 4 shared J. W. Sawicki· 3 shared A. Gusa· 2 shared D. Chang-Yen· 2 shared E. M. Shouse· 2 shared J. Heitman· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

A. J. Radosevich

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Metabolite Fingerprinting for Phenotypic Screening by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

A. N. Joignant, F. Pu, S. M. McLoughlin, J. W. Sawicki, A. J. Radosevich, R. Ma, J. D. Williams, S. M. Gopalakrishnan, N. L. Elsen

This paper demonstrates a high-throughput phenotypic screening method using IR-MALDESI mass spectrometry to identify glutaminase inhibitors and distinguish them from nuisance compounds.

bioRxiv · Dec 20, 2023Cell Biology

The Ivory-billed Woodpecker: audio evidence and analyses from Southeast United States 2022

J. D. Williams

The paper was withdrawn due to data ownership concerns and disagreements with conclusions.

bioRxiv · Apr 6, 2023 · PreprintAnimal Behavior & Cognition

A New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

F. Pu, A. J. Radosevich, B. G. Bruckner, D. A. Fontaine, S. C. Panchal, J. D. Williams, S. M. Gopalakrishnan, N. L. Elsen

This paper introduces a high-throughput label-free cellular pharmacodynamic assay using IR-MALDESI to identify glutaminase inhibitors and confirm hits with mass spectrometry-based assays.

bioRxiv · Jan 30, 2023Biochemistry

Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformans

A. Gusa, V. Yadav, C. Roth, J. D. Williams, E. M. Shouse, P. M. Magwene, J. Heitman, S. Jinks-Robertson

The paper investigates heat stress-induced transposon mobility in Cryptococcus deneoformans using whole-genome sequencing, finding increased retroelement mobilization at 37°C compared to 30°C.

bioRxiv · Jun 10, 2022Microbiology

High Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

F. Pu, S. A. Ugrin, A. J. Radosevich, D. Chang-Yen, J. W. Sawicki, N. N. Talaty, N. L. Elsen, J. D. Williams

This paper demonstrates the use of IR-MALDESI-MS for high throughput intact protein analysis in drug discovery, achieving faster sample rates than traditional ESI-MS methods.

bioRxiv · Nov 8, 2021Biochemistry

Ultrahigh-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

A. J. Radosevich, F. Pu, D. Chang-Yen, J. W. Sawicki, N. N. Talaty, N. L. Elsen, J. D. Williams, J. Y. Pan

This paper develops an ultrahigh-throughput IR-MALDESI mass spectrometry method capable of analyzing 22 samples per second with low carryover and high repeatability.

bioRxiv · Oct 25, 2021 · PreprintPharmacology & Toxicology

Transposon mobilization in the human fungal pathogen Cryptococcus deneoformans is mutagenic during infection and promotes drug resistance in vitro

A. Gusa, J. D. Williams, J.-E. Cho, A. Floyd-Averette, S. Sun, E. M. Shouse, J. Heitman, A. Alspaugh, S. Jinks-Robertson

This study shows that transposon mobilization in Cryptococcus deneoformans increases mutagenesis and drug resistance during infection and in vitro.

Proceedings of the National Academy of Sciences · Apr 17, 2020Peer-reviewedMicrobiology

Second Harmonic Generation Spectroscopy of Membrane Probe Dynamics in Gram-Positive Bacteria

L. N. Miller, W. T. Brewer, J. D. Williams, E. M. Fozo, T. R. Calhoun

The paper uses SHG and two-photon fluorescence to study membrane probe dynamics in two gram-positive bacteria, showing SHG's ability to detect molecular movement and ordering, with differences observed between species.

bioRxiv · May 24, 2019Biophysics