A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling
Y. Yang, D. Jayaprakash, R. Hollingworth, S. Chen, A. Jablonski, E. Mutter-Rottmayer, Y. Gao, J. Anand Ramlal, J. An, X. Chen, K. Pearce, S.-A. Blanchet, A. Fradet-Turcotte, G. Stewart, C. Vaziri
This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.
bioRxiv · Mar 17, 2021 · PreprintCancer Biology