J. An

Molecular evaluation of Conogethes punctiferalis (Guenee, 1854): Species status and intraspecific divergence

The paper evaluates the species status and intraspecific divergence of Conogethes punctiferalis using mitochondrial DNA sequences and species delimitation methods.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease

This study demonstrates that IL-10-producing group 2 innate lymphoid cells (ILC210) can suppress Graft-versus-Host Disease (GVHD) in a humanized model without compromising graft-versus-leukemic effects.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

A multi-omic Nicotiana benthamiana resource for fundamental research and biotechnology

The paper provides high-quality genome assemblies and multi-omic datasets for Nicotiana benthamiana strains LAB and QLD, along with SNP mapping, to enhance their use in research and biotechnology.

The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development

The paper shows that E2Fs and RBR are essential for quiescence in plant development, with E2Fs specifically controlling both G1-S and G2-M targets.

miR167-ARF8, an auxin-responsive module involved in the formation of root-knot nematode-induced galls in tomato

The paper identifies miR167-ARF8 as a regulatory module involved in root-knot nematode-induced gall formation in tomato by analyzing miRNA and transcriptome data.

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting

This paper analyzes western blot practices in top neuroscience and cell biology journals, finding widespread issues with image display and methods reporting, and provides tools to improve transparency and reproducibility.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis

This study identifies a transcriptional network involving SCL28 and AtSMOS1 that regulates cell size and number in Arabidopsis by controlling G2 phase transitions through CDK inhibitors.

A Degenerate PCNA-Interacting Peptide (DPIP) box targets RNF168 to replicating DNA to limit 53BP1 signaling

This study identifies a non-canonical role of RNF168 at DNA replication forks, showing it suppresses 53BP1 signaling through PCNA binding, independent of its canonical DSB response function.

Parietal cell-Specific SLC26A9 Deletion induces spontaneous Gastric Carcinogenesis in Mice

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

Cross-Protection Against Zika Virus Infection Conferred by a Live Attenuated Japanese Encephalitis SA14-14-2 Vaccine

This study shows that the JE vaccine SA14-14-2 protects mice against ZIKV through cross-reactive T cell immunity rather than antibodies.

Functional Interrogation of HOXA9 Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.

This study shows UVB exposure triggers local and systemic Type I interferon responses in mice, which are largely cGAS-dependent and contribute to disease flares in SLE.

For running or burying -- The toe fringe of Phrynocephalus mystaceus is important

This study removes toe fringes from Phrynocephalus mystaceus to test their impact on locomotor and sand-diving performance, finding that toe fringe area significantly affects both.

In vitro pancreatic islet cluster expansion facilitated by hormones and chemicals

This study describes a method to expand pancreatic islet clusters in vitro using hormones and chemicals, resulting in functional islet-like structures with cell type markers.

Genetic diversity analysis of an isolate of microsporidia infesting Athetis lepigone

The paper analyzes genetic diversity in microsporidia LEP9557 using PCR, cloning, and sequencing of SSU rDNA, ITS, and IGS regions, revealing higher polymorphism in ITS and IGS than SSU rDNA.