Author

A. Jacquel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Kerreneur· 2 shared G. Robert· 2 shared P. Auberger· 2 shared A. Porterszman· 1 shared A. R. Martin· 1 shared A. Vigroux· 1 shared B. E. Torbett· 1 shared B. Vianay· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

E. Kerreneur

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

AML patient blasts exhibit polarization defect upon interaction with bone marrow stromal cells.

K. Saadallah, B. Vianay, L. Bonnemay, H. Pasquer, L. Kelly, C. Culeux, R. Marie, S. Fodil, P. Chaintreuil, E. Kerreneur, A. Jacquel, E. Raffoux, R. Nizard, L. Blanchoin, L. Benajiba, M. Thery

This study shows AML blasts fail to polarize when interacting with healthy stromal cells, and AML-derived stromal cells impair polarization of healthy HSPCs and AML blasts.

bioRxiv · Jun 21, 2024Cancer Biology

Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis

C. Favreau, C. Savy, M. Bourgoin, T. Botton, S. Bailly, F. Granger, C. Birck, M. Zerhouni, E. Kerreneur, A. Vigroux, J. Dussart-Gautheret, M.-L. Arcangeli, T. Cluzeau, A. Porterszman, S. Rocchi, , G. Robert

The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.

bioRxiv · Apr 3, 2024 · PreprintBiochemistry

HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia differentiation

S. Rafiq, I. Mungure, N. J. Niklaus, S. Mueller, A. Jacquel, G. Robert, P. Auberger, B. E. Torbett, S. Muller, M. P. Tschan, M. Humbert

This study shows that HSPA8 chaperone complex regulates chaperone-mediated autophagy (CMA) during APL differentiation, with CMA downregulation required for neutrophil maturation.

bioRxiv · Aug 7, 2022 · PreprintCancer Biology