S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.
A. Amar-Schwartz, V. Ben Hur, A. Jbara, Y. Cohen, G. D. Barnabas, Z. Siegfried, B. Mashahreh, F. Hassouna, A. Shilo, M. Abu-Odeh, M. Berger, R. Wiener, R. I. Aqeilan, T. Geiger, R. Karni
This study identifies S6K1's role in DNA repair by phosphorylating Cdk1 and MSH6, showing its impact on cell cycle arrest and mismatch repair in breast cancer.
bioRxiv · Mar 25, 2022 · PreprintCancer Biology