T. Geiger

Chemoresistome Mapping in Individual Breast Cancer Patients Unravels Diversity in Dynamic Transcriptional Adaptation

The paper maps chemoresistome dynamics in breast cancer patients to identify patient-specific resistance mechanisms and vulnerabilities.

Metabolic plasticity of T-cell therapies: multi-omic profiling of interacting human tumor-infiltrating lymphocytes and autologous tumor adoptive cell therapy

This study profiles the metabolic interactions between TILs and autologous tumor cells in ACT, finding that responder TILs are more efficient at fatty acid oxidation under starvation.

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.

This study identifies S6K1's role in DNA repair by phosphorylating Cdk1 and MSH6, showing its impact on cell cycle arrest and mismatch repair in breast cancer.

Proteomic landscape of multi-layered breast cancer internal tumor heterogeneity

This study presents a large-scale proteomic analysis of 330 tumor regions in breast cancer, revealing significant internal proteomic heterogeneity and functional differences between homogeneous and heterogeneous tumors.

Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome

This study shows that removing a primary tumor can cause small metastases to regress, but not larger ones, and identifies tumor-secreted factors that promote early metastatic growth.

Proteomic and Genomic Signatures of Repeat-instability in Cancer and Adjacent Normal Tissues

The paper quantifies repeat-instability in cancer and normal tissues using proteomic and genomic data, identifying tumor-specific signatures linked to progression and tumorigenic state.