Compensatory adaptation does not fully alleviate the costs associated with rifampicin resistance and occurs predominantly through off-target mutations
Y. Cohen, G. A. Rozen, P. Pennings, S. Katz, R. Hershberg
This study shows compensatory mutations do not fully offset rifampicin resistance costs and mostly occur outside the drug target, with convergent pathways across populations.
bioRxiv · Jan 13, 2023 · PreprintEvolutionary Biology