R. Wiener

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

Structural study of UFL1-UFC1 interaction uncovers the importance of UFL1 N-terminal helix for ufmylation

This study reveals the role of UFL1's N-terminal helix in binding UFC1 and ufmylation, uncovering a helix-mediated regulatory mechanism in the E1-E2-E3 cascade.

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.

This study identifies S6K1's role in DNA repair by phosphorylating Cdk1 and MSH6, showing its impact on cell cycle arrest and mismatch repair in breast cancer.

Regulation of major bacterial survival strategies by transcript sequestration in a membraneless organelle

The paper shows that TmaR-mediated liquid-liquid phase separation in E. coli regulates sugar metabolism and enables bacterial survival strategies like motility and biofilm formation.

Structural basis for long-chain isoprenoids synthesis by cis-prenyltransferases

This paper investigates the structural basis for long-chain isoprenoid synthesis by human cis-prenyltransferase, revealing a mechanism for directional product synthesis and membrane insertion.

RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment

This study shows that RelA-mediated Hfq hexamerization requires RNA binding to Hfq monomers, challenging the idea that only hexamers can bind RNA.