Nitrative signaling into cardiac lactate dehydrogenase Trp324 modulates active site loop mobility and activity under metabolic stress
C. Nogales, J. Frihoff, D. Thoenges, R. B. Sessions, A. Sickmann, T. Nedvetskaya, C. Ibarra-Alvarado, V. Schmitz, P. Rosen, A. Goedecke, A. Jovanovic, D. H. Perlman, A. Klinke, S. Baldus, A. I. Casas, , H. H. H. W. Schmidt
This study identifies Trp324 nitration in lactate dehydrogenase as a physiological signaling mechanism modulating enzyme activity under metabolic stress.
bioRxiv · Jan 15, 2019 · PreprintBiochemistry