Author

S. Baldus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Mehrkens· 4 shared G. Sengle· 3 shared M. Adam· 3 shared S. Geissen· 3 shared A. Hof· 2 shared A. Klinke· 2 shared F. R. Picard· 2 shared F. S. Nettersheim· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersCell Biology

D. Mehrkens

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation

M. Vantler, M. Schorscher, E. M. Berghausen, M. Zierden, J. Spitzer, J. B. Moore, D. Wong, Z. Li, M. Wissmueller, L. Gnatzy-Feik, D. Unnersjoe-Jess, L.-M. A. Zimmermann, M. Grandoch, D. Mehrkens, M. Adam, , S. Rosenkranz

This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.

bioRxiv · Dec 1, 2022 · PreprintCell Biology

Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

L.-M. A. Zimmermann, A. G. Furlan, D. Mehrkens, S. Geissen, A. V. Zuk, G. Pryymachuk, N. Pykarek, T. van Beers, D. Sonntag-Bensch, J. Marzi, K. Schenke-Layland, J. Brinckmann, M. Grandoch, P. Zigrino, S. Baldus, G. Sengle

This study shows that targeting MMP-13 prevents aortic aneurysm formation in Marfan mice by reducing collagen degradation and BMP activity.

bioRxiv · Nov 30, 2022 · PreprintBiochemistry

Inhibition of myeloperoxidase prevents thoracic aortic aneurysm formation in Marfan mice

D. Mehrkens, F. S. Nettersheim, F. Ballmann, J. Bastigkeit, A. Brueckner, J. Dohr, S. Geissen, L. De Vore, P. Schelemei, F. R. Picard, M. Kochen, S. Braumann, W. Kreuzberg, A. Hof, H. Guthoff, , H. Winkels

This study shows that inhibiting myeloperoxidase prevents thoracic aortic aneurysms in Marfan mice by reducing inflammation and extracellular matrix damage.

bioRxiv · Nov 24, 2022 · PreprintImmunology

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis

H. N. Nemade, D. Mehrkens, H. S. Lottermoser, Z. E. Yilmaz, P. Schelemei, F. R. Picard, S. Geissen, G. F. Schwab, F. F. Hoyer, H. Guthoff, A. Hof, F. S. Nettersheim, A. Sachinidis, H. Winkels, S. Baldus, , M. Mollenhauer

This study shows that inhibiting MLKL reduces abdominal aortic aneurysm development by preventing smooth muscle cell necroptosis and associated inflammation.

bioRxiv · Nov 24, 2022Cell Biology

Nitrative signaling into cardiac lactate dehydrogenase Trp324 modulates active site loop mobility and activity under metabolic stress

C. Nogales, J. Frihoff, D. Thoenges, R. B. Sessions, A. Sickmann, T. Nedvetskaya, C. Ibarra-Alvarado, V. Schmitz, P. Rosen, A. Goedecke, A. Jovanovic, D. H. Perlman, A. Klinke, S. Baldus, A. I. Casas, , H. H. H. W. Schmidt

This study identifies Trp324 nitration in lactate dehydrogenase as a physiological signaling mechanism modulating enzyme activity under metabolic stress.

bioRxiv · Jan 15, 2019 · PreprintBiochemistry