Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
V. Q.-H. Trinh, K. E. Ankenbauer, S. M. Torbit, J. Liu, M. Batardiere, B. Kumar, H. C. Maurer, F. Revetta, Z. Chen, A. Kruse, A. Judd, C. Copeland, J. Wong, O. Ben-Levy, B. Jarvis, , K. E. DelGiorno
This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.
bioRxiv · Feb 25, 2024 · PreprintCancer Biology