B. Kumar

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descent

The paper identifies PZP stromal cells enriched in African Ancestry women that may contribute to metaplastic breast cancer incidence through epithelial communication and STAT3 activation.

Prospective Fecal Microbiomics Biomarkers for Chronic Wasting Disease

This study identifies fecal microbiome and metabolomics biomarkers that can differentiate CWD-positive from CWD-negative deer with 70% accuracy.

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms

This study identifies the iron acquisition mechanisms used by Staphylococcus lugdunensis during infection, showing that both heme and non-heme iron systems are required for proliferation in mice.

Knowledge, Attitude and Practices towards COVID-19 Guidelines among Students in Bangladesh

This study assesses knowledge, attitude, and practices (KAP) of COVID-19 guidelines among Bangladeshi students, finding high knowledge and positive attitude but poor adherence, recommending delayed reopening of schools.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer

The paper identifies antagonistic roles of CBX2 and CBX7 in breast cancer metabolism using multi-omics data and validates their impact on tumor aggressiveness and drug response.

Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate

The paper reports the production of a multi-antigenic SARS CoV-2 virus-like particle (VLP) in Saccharomyces cerevisiae as a vaccine candidate, confirmed by TEM and analytical data.

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

Disaggregated Level Child Morbidity in Bangladesh: An Application of Small Area Estimation Method

This study uses small area estimation to estimate child morbidity rates at micro-level administrative units in Bangladesh, revealing significant variation compared to national levels.

AML ImmunoPET: 64Cu-DOTA-anti-CD33 PET-CT imaging of AML in Xenograft mouse model

This paper develops a 64Cu-DOTA-anti-CD33 PET-CT imaging method for detecting AML in xenograft mouse models with high sensitivity and specificity, showing spatial heterogeneity in disease distribution.

Development of Kinetic Modeling to Assess Multi-functional Vascular Response to Low Dose Radiation in Leukemia

The paper uses intravital multiphoton microscopy to assess vascular parameters in a leukemia mouse model and shows radiation therapy improves drug uptake.

Functional Balance between TCF21-Slug defines phenotypic plasticity and sub-classes in high-grade serous ovarian cancer

The paper identifies TCF21-Slug interactions that define phenotypic plasticity and sub-classes in high-grade serous ovarian cancer.

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer

The paper quantifies miRNA expression in prostate stroma and epithelium, finding cell-type specific patterns and associations with prostate cancer recurrence.