J. Wong

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis

This study characterizes the skeletal muscle arginine methylome in health and disease, revealing significant remodeling in ALS and identifying potential therapeutic targets.

Bacteroides thetaiotaomicron metabolic activity decreases with polysaccharide molecular weight

This study shows that Bacteroides thetaiotaomicron's metabolic activity decreases with increasing polysaccharide molecular weight, affecting bacterial growth and community dynamics.

Genome assembly of the bearded iris Iris pallida Lam.

The paper reports the genome assembly of Iris pallida Lam. using long-read sequencing, providing a high-quality reference for studying secondary metabolite biosynthesis.

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Interdependence of a microtubule polymerase and a motor protein in establishment of kinetochore end-on attachments

This study shows that Kip3 and Stu2 work together in yeast to establish proper kinetochore-microtubule attachments during mitosis.

Long-term survival and induction of operational tolerance to murine islet allografts through the co-transplantation of cyclosporine A eluting microparticles

This study shows that localized cyclosporine A delivery via microparticles combined with CTLA4-Ig reduces islet allograft rejection and induces operational tolerance in mice.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

Taste adaptations associated with host-specialization in the specialist Drosophila sechellia

This study identifies taste adaptations in Drosophila sechellia that contribute to its host-specialization, including reduced sensitivity to bitter compounds and increased appetite for host fatty acids.

Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project

This study integrates genomic and transcriptomic analysis of intraductal papillary mucinous neoplasms (IPMNs) to identify molecular features associated with progression to high-grade lesions and cancer.

AIRRscape: an interactive tool for exploring B-cell receptor repertoires and antibody responses

AIRRscape is an interactive tool for exploring B-cell receptor repertoires and antibody responses across multiple datasets, revealing convergent sequences in viral immunity.

Genome size variation and evolution during invasive range expansion in an introduced plant

The paper investigates genome size variation in yellow starthistle across its invasive range in California, finding associations with flowering time and elevation, and suggesting genetic drift and selection pressures.

Variation in microbial feature perception in the Rutaceae family with immune receptor conservation in citrus

The paper examines variation in immune perception of microbial features across Rutaceae species, finding that receptor sequences are conserved despite differences in immune responses.

Reconstitution of Kinetochore and Microtubule Dynamics Reveals a Role for a Kinesin-8 in Establishing End-on Attachments

This study reconstitutes kinetochore-microtubule interactions in yeast to show that Kip3 enables directional kinetochore movement and end-on attachment by regulating microtubule dynamics.

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae

This study identifies and characterizes OmpK36 loop 3 insertions in Klebsiella pneumoniae, showing their role in carbapenem resistance and clonal spread across different geographic regions.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

A Fully Implantable Wireless Bidirectional Neuromodulation System for Mice

This paper presents a fully-implantable wireless neuromodulation system for mice capable of bidirectional signal exchange and long-term functionality.

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

Class I Histone Deacetylases (HDAC1-3) are Histone Lysine Delactylases

This study identifies HDAC1-3 and SIRT1-3 as enzymes that remove histone lactylation marks, contrasting with the known role of acetylation.

MinION barcodes: biodiversity discovery and identification by everyone, for everyone

This paper introduces a low-cost, accessible workflow and software for DNA barcoding using MinION sequencing, achieving high accuracy comparable to Sanger and Illumina methods.

Implant- and anesthesia-related factors affecting threshold intensities for vagus nerve stimulation

This study identifies implant- and anesthesia-related factors influencing threshold intensities for vagus nerve stimulation, showing neural thresholds are lower than physiological thresholds and that anesthesia type and implant age significantly affect these thresholds.

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

This paper introduces GETMap, a method to determine tissue origin of plasma DNA carrying genetic variants, validated across prenatal testing, transplantation, and oncology scenarios.

OmpK36 and TraN facilitate conjugal transfer of the Klebsiella pneumoniae carbapenem resistance plasmid pKpQIL

This study identifies OmpK36 and TraN as key factors for conjugative transfer of the K. pneumoniae plasmid pKpQIL, revealing a novel receptor mechanism for IncF plasmids.

Rag1D600A, a novel catalytically inactive RAG mouse model

This paper introduces a novel Rag1D600A mouse model with impaired RAG activity, showing developmental blocks in B and T cell lineages.

PI3K/AKT inhibition in tumor propagating cells of DLBCL reverses R-CHOP resistance by destabilizing SOX2

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.