Author

A. K. Howe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

K. V. Svec· 3 shared M. Kang· 3 shared A. J. McKenzie· 2 shared H. Naughton· 2 shared A. A. Herppich· 1 shared A. J. Senatore· 1 shared B. T. Goult· 1 shared J. Yan· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

K. V. Svec

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5 papers

Recent·Most cited

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

M. Kang, Y. Otani, Y. Guo, J. Yan, B. T. Goult, A. K. Howe

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

Proceedings of the National Academy of Sciences · Mar 21, 2024Peer-reviewedCell Biology

Protein Kinase A is Functional Component of Focal Adhesions

M. Kang, A. J. Senatore, H. Naughton, M. McTigue, R. J. Beltman, A. A. Herppich, M. K. H. Pflum, A. K. Howe

This study identifies PKA as a functional component of focal adhesions and identifies Tns3 as a novel PKA substrate, revealing a new pathway for phospho-regulation in FA dynamics.

bioRxiv · Aug 18, 2023Cell Biology

Protein Kinase A Activity In The Leading Edge Of Migrating Cells Is Dependent On The Activity Of Focal Adhesion Kinase

K. V. Svec, M. Kang, A. K. Howe

This study shows that FAK activity is required for localized PKA regulation in migrating cells, establishing a novel connection between adhesion signaling and PKA activity.

bioRxiv · Sep 17, 2022 · PreprintCell Biology

Protein Kinase A activity is regulated by actomyosin contractility during cell migration and is required for durotaxis

A. J. McKenzie, T. F. Williams, K. V. Svec, A. K. Howe

This study shows PKA activity is regulated by actomyosin contractility during cell migration and is necessary for durotaxis.

bioRxiv · Aug 15, 2018Cell Biology

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

A. J. McKenzie, S. R. Hicks, K. V. Svec, H. Naughton, Z. L. Edmunds, A. K. Howe

This study shows that matrix stiffness affects ovarian cancer cell behavior, including migration and spheroid disaggregation, through mechanotransduction pathways.

bioRxiv · Dec 21, 2017Cell Biology