J. Yan

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing

This paper introduces CODEMax and CODEMax(exo+) genome editing systems that enable efficient and precise search-and-replace editing in human cells with reduced off-target effects.

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

This study shows proteasome inhibition alters DNA methylation in colorectal cancer by reducing DNMT1 and DNMT3B synthesis via AKT/mTOR inactivation.

Comprehensive profiling of genomic invertons in defined gut microbial community reveals associations with intestinal colonization and surface adhesion

The paper develops a method to detect invertons in gut microbiome metagenomic data and finds associations between inverton dynamics and intestinal colonization and surface adhesion.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

The focal adhesion protein talin is a mechanically-gated A-kinase anchoring protein (AKAP)

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

Regulation of Arabidopsis polyamine acetylation by NATA1 and NATA2

This study investigates the role of NATA1 and NATA2 in regulating polyamine acetylation in Arabidopsis, showing that NATA2 is heat-inducible and beneficial under heat stress, while its double knockout is lethal.

Comparative analyses of adsorbed circulating proteins in the PMMA and PES hemodiafilters in patients on predilution online hemodiafiltration

This study compares protein adsorption by PMMA and PES hemodiafilters in OL-HDF, finding PMMA adsorbs more inflammatory proteins like IL-6 and beta-2 microglobulin.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression

This study investigates how GC cytokines regulate EBV latency gene expression and epigenetic remodeling, revealing distinct roles for STAT3 and STAT5 in silencing EBNA and activating LMP1 promoters.

Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor

This study shows that co-administering immunogenic MVA and G-CSF activates neutrophils to kill MPNST tumors in a murine model.

A human immune/muscle xenograft model of FSHD muscle pathology

This study develops a humanized mouse model to investigate the role of innate immunity in FSHD muscle pathology and identifies immune cell accumulation and complement gene expression in FSHD muscle xenografts.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

In-situ Single-Molecule Investigations of the Impacts of Biochemical Perturbations on Conformational Intermediates of Monomeric α-Synuclein

This study uses in-situ single-molecule techniques to identify a partially folded conformation of α-synuclein and shows its sensitivity to biochemical perturbations and drugs.

Unraveling the Dual-Mode Impact on Tension Gauge Tethers' Mechanical Stability

This paper develops a model to predict the tension-dependent lifetime of Tension Gauge Tethers (TGTs) and validates it with experimental data.

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.

Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

The paper develops concatenated BK channel constructs to study subunit stoichiometry in gating, finding distinct stoichiometric effects of LRRC26, pore, and selectivity filter mutations.

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

This study shows high-intensity ultrasound increases anti-inflammatory EV secretion from skeletal myotubes by raising intracellular calcium levels, which reduces pro-inflammatory gene expression in macrophages.

The mechanical response of vinculin

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

This study identifies PI4KIII's role in promoting liver cancer invasiveness through cytoskeletal reorganization via PIK3C2γ and Akt2/paxillin-cofilin signaling.

Root branching in salt requires auxin-independent modulation of LBD16 function

The paper shows that salt stress modulates lateral root development through an auxin-independent pathway involving ZAT6 and LBD16.

Lipoarabinomannan regulates septation in Mycobacterium smegmatis

This study shows that lipoarabinomannan (LAM) regulates septation in Mycobacterium smegmatis, affecting cell envelope integrity and septal placement.

A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure

This paper develops an injectable hydrogel depot technology for sustained rabies vaccine delivery, showing a single dose can match a standard prime-boost regimen in mice.

Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptors

This study examines how mechanical forces affect the GAIN domains of three aGPCRs, showing force-induced destabilization and detachment, supporting the mechanical activation hypothesis.

A novel cancer-associated cassette exon in TLN1 alters Talin 1 mechanosensitivity

The paper identifies a cancer-associated exon in TLN1 that alters mechanosensitivity by affecting R1-R2 switch dynamics and vinculin binding.

The Alfin-like transcription factor GmAlfin09 regulates endoplasmic reticulum stress in soybean via a peroxidase GmPRDX6

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.