B. T. Goult

This study identifies talin1 as a mechanically-gated AKAP that binds PKA through a force-dependent interaction in focal adhesions.

This study identifies TLNRD1 as a CCM complex component that regulates endothelial barrier integrity by modulating actin bundling.

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

The paper identifies a cancer-associated exon in TLN1 that alters mechanosensitivity by affecting R1-R2 switch dynamics and vinculin binding.

This paper determines the structure of the talin-KANK1 complex, revealing how KANK1 binds talin and its localization in focal adhesions is regulated by actomyosin tension.

The paper identifies lamellipodin as a novel cargo of myosin-X and shows it is transported to filopodia tips to support their formation and stability.

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

The paper shows that talin's precomplex with vinculin accelerates adhesion maturation by enhancing vinculin recruitment and force transmission.

This study identifies TLNRD1 as an actin-bundling protein that promotes filopodia formation and cell migration by interacting with LD-motif proteins like RIAM and KANK.

The paper identifies MYO10 and talin as key regulators of integrin activity in filopodia, proposing a two-step model for integrin activation.

This study analyzes talin-1 mutations from the COSMIC database to assess their impact on cell adhesion, migration, and cancer progression using bioinformatics and experimental approaches.