Author

A. K. Sharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Ecology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. M. Brown· 4 shared J. Weger-Lucarelli· 2 shared A. Ceci· 1 shared A. R. Goldberg· 1 shared B. Craige· 1 shared C. A. Cridland· 1 shared C. D. Kailing· 1 shared C. Roby· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiophysics

A. M. Brown

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Author profile →

4 papers

Recent·Most cited

Mechanistic insights into transport models of the sphingolipid transport protein, Spinster homolog 2 (Spns2), using MD simulations

A. K. Sharp, M. Q. LoPresti, A. M. Brown

This study uses MD simulations to investigate the structural mechanisms of S1P transport by Spns2, identifying key residues and a rocker-switch model for potential inhibitor development.

bioRxiv · Mar 10, 2024 · PreprintBiophysics

Widespread exposure to SARS-CoV-2 in wildlife communities

A. R. Goldberg, K. E. Langwig, K. L. Brown, J. M. Marano, P. Rai, K. M. King, A. K. Sharp, A. Ceci, C. D. Kailing, M. J. Kailing, R. Briggs, M. G. Urbano, C. Roby, A. M. Brown, J. Weger-Lucarelli, , J. R. Hoyt

The paper documents SARS-CoV-2 exposure in six wildlife species and finds higher seroprevalence in areas with high human activity, suggesting human-to-animal transmission events.

bioRxiv · Nov 4, 2022Ecology

A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

L. Kang, G. He, A. K. Sharp, X. Wang, A. M. Brown, P. Michalak, J. Weger-Lucarelli

The paper identifies a selective sweep in the Spike gene of SARS-CoV-2 that enhanced human adaptation by improving binding to human ACE2 and replication in human cells.

bioRxiv · Feb 13, 2021Microbiology

Inositol Trisphosphate Kinase and Diphosphoinositol Pentakisphosphate Kinase Enzymes Constitute the Inositol Pyrophosphate Synthesis Pathway in Plants

O. Adepoju, S. P. Williams, B. Craige, C. A. Cridland, A. K. Sharp, A. M. Brown, E. Land, I. Y. Perera, D. Mena, P. Sobrado, G. E. Gillaspy

This paper identifies AtITPK enzymes as the missing components in the plant inositol pyrophosphate synthesis pathway and shows their subcellular localization and effects on InsP7 and InsP8 levels.

bioRxiv · Aug 5, 2019 · PreprintPlant Biology