L. Kang

A Novel Role of Hyaluronan and its Membrane Receptors, CD44 and RHAMM in Obesity-Related Glomerulopathy

This study identifies HA and its receptors CD44/RHAMM as key drivers of obesity-related glomerulopathy, showing their role in renal inflammation, fibrosis, and dysfunction, and suggests they as therapeutic targets.

Unravelling an Efficient O2/Reductant-Dependent Catalytic Route in Heme Peroxygenases for Sustainable Applications

This paper identifies an O2/reductant-dependent catalytic pathway in heme peroxygenases that avoids H2O2-induced inactivation, enabling efficient and sustainable chemical transformations.

Recombinant expression, purification, and antifungal activity of the novel antimicrobial peptide TaW662

This study identifies and characterizes TaW662, an antifungal peptide from wheat, showing inhibition of Blumeria graminis f. sp. tritici growth and potential as a fungicide.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

Extracellular Matrix Abnormalities Contribute to Cardiac Insulin Resistance and Associated Dysfunction in Diet-induced Obese Mice

This study shows that ECM abnormalities contribute to cardiac insulin resistance and dysfunction in obese mice, with potential therapeutic implications.

Deletion of CD44 promotes adipogenesis by regulating PPARγ and cell cycle-related pathways

This study shows that deleting CD44 in preadipocytes promotes adipogenesis by suppressing PPARγ and cell cycle pathways, suggesting CD44 as a therapeutic target for obesity-related metabolic diseases.

Automated whole-organ histological imaging assisted with ultraviolet-excited sectioning tomography and deep learning

This paper introduces HistoTRUST, a pipeline combining ultraviolet-excited sectioning tomography and deep learning to rapidly generate 3D histological images of whole organs.

RBP-J regulates homeostasis and function of circulating Ly6C lo monocytes

This study shows RBP-J regulates blood Ly6Clo monocytes and their derived lung macrophages by controlling CCR2 expression.

Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform

This study evaluates immune responses to an ISFV-based Zika vaccine, showing neutralizing antibodies and T-cells contribute to protection.

Deep Learning Assisted Smartphone-based Quantitative Microscopy for Label-free Hematological Analysis

This paper introduces a smartphone-based autofluorescence microscopy system enhanced with deep learning for label-free hematological analysis, enabling rapid and accurate blood cell classification.

Label-free and non-destructive pathology of human lung adenocarcinomas with ultraviolet single-plane illumination microscopy

This paper introduces MUSI, a rapid, label-free imaging method for lung adenocarcinomas, showing it can differentiate subtypes with resolution comparable to FFPE histology.

Potent Immunogenicity and Broad-Spectrum Protection Potential of Microneedle Array Patch-Based COVID-19 DNA Vaccine Candidates Encoding Dimeric RBD Chimera of SARS-CoV and SARS-CoV-2 Variants

This study develops DNA vaccines encoding chimeric RBDs of SARS-CoV and SARS-CoV-2 variants, showing potent immunogenicity and broad neutralization against multiple variants.

ILC3s select for RORγt+ Tregs and establish tolerance to intestinal microbiota

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

This study identifies how CD11b agonists trigger STING-interferon signaling in tumor-associated macrophages to enhance anti-tumor immunity in mouse models and human cancer patients.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Three-dimensional label-free histological imaging of whole organs by microtomy-assisted autofluorescence tomography

This paper introduces MATE, a label-free 3D histological imaging technique for whole organs, enabling high-resolution visualization and quantitative analysis of tissue structures without staining or clearing.

Investigation on the changes of Bifidobacterium and lactic acid bacteria in soybean meal fermented feed

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

Three-dimensional Multicolor Subcellular Imaging by Fast Serial Sectioning Tomography for Centimeter-scale Specimens

This paper introduces TRUST, a fast 3D imaging method for centimeter-scale specimens, enabling multicolor subcellular imaging without extensive sample preparation.

Non-canonical Function of a Hif-1α Splice Variant Contributes to the Sustained Flight of Locusts

This study identifies a non-canonical Hif-1 splice variant in locusts that supports sustained flight by promoting glucose oxidation and redox homeostasis under aerobic conditions.

Speckle illumination microscopy enables slide-free and non-destructive pathology of human lung adenocarcinoma

This paper introduces HiLo microscopy for rapid, non-destructive lung adenocarcinoma pathology with high resolution and speed, comparable to gold-standard histology.

High-throughput, label-free and slide-free histological imaging by computational microscopy and unsupervised learning

This paper introduces CHAMP, a computational microscopy method for high-throughput, label-free histological imaging, and demonstrates its ability to generate virtually stained images through unsupervised learning.

A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation

The paper identifies a selective sweep in the Spike gene of SARS-CoV-2 that enhanced human adaptation by improving binding to human ACE2 and replication in human cells.

Oxidized LDL but not angiotensin II induces the interaction between LOX-1 and AT1 receptors

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

Enhanced skin permeation of a novel peptide via structural modification, chemical enhancement, and microneedles

The paper evaluates methods to enhance skin permeation of decapeptide-12, finding that microneedle patches with palmitate-modified peptides provide the best delivery.

Red and black: A β-carotene-binding protein carrying a red pigment regulates body-color transition in locusts

This study identifies a β-carotene-binding protein that regulates body color transition in locusts by modulating red pigment accumulation.