Unique role and vulnerability of EP300 KIX domain in small-cell lung cancer
K.-B. Kim, A. Kabra, D.-W. Kim, Y. Xue, P.-C. Hou, Y. Zhou, L. Miranda, X. Shi, T. P. Bender, J. H. Bushweller, K.-S. Park
The paper identifies the EP300 KIX domain as a critical driver of SCLC and shows that targeting this domain can inhibit tumor growth.
bioRxiv · Jun 3, 2021 · PreprintCancer Biology