β1 integrin is a sensor of blood flow direction
I. Xanthis, C. Souilhol, J. Serbanovic-Canic, H. Roddie, A. Kalli, M. Fragiadaki, R. Wong, D. Shah, J. Askari, L. Canham, N. Akhtar, S. Feng, V. Ridger, J. Waltho, E. Pinteaux, , P. Evans
This study identifies β1 integrin as a sensor for blood flow direction in endothelial cells, showing it is activated by unidirectional but not bidirectional shear stress.
bioRxiv · Jan 3, 2019Cell Biology