Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis
M. Ma, S. Ghosh, D. Tavernari, A. Katarkar, A. Clocchiatti, L. Mazzeo, A. Samarkina, J. Epiney, Y.-R. Yu, P.-C. Ho, M. P. Levesque, B. Özdemir, G. Ciriello, R. Dumme, G.-P. Dotto
This study shows that androgen receptor signaling promotes melanoma cell growth and tumorigenesis, with AR inhibition reducing proliferation, enhancing DNA repair, and inducing immune responses.
bioRxiv · May 26, 2020Cancer Biology