P.-C. Ho

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems

This study shows that inducing mitophagy with Urolithin-A restores hematopoietic and immune system function in aged mice.

CD8+ T Cell Metabolic Rewiring Defined by Single-Cell RNA-Sequencing Identifies a Critical Role of ASNS Expression Dynamics in T Cell Differentiation

This study uses scRNA-seq to analyze CD8+ T cell metabolic dynamics during activation and differentiation, identifying ASNS expression dynamics as critical for determining T cell fate.

Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

Sustained Androgen Receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

This study shows that androgen receptor signaling promotes melanoma cell growth and tumorigenesis, with AR inhibition reducing proliferation, enhancing DNA repair, and inducing immune responses.

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors

The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.