Abuse liability, antinociceptive, and discriminative stimulus properties of IBNtxA
A. Islam, M. A. Rahman, M. B. Brenner, A. Moore, A. Kellmyer, H. Buechler, F. DiGiorgio, V. Verchio, L. McCracken, M. Sumi, R. Hartley, J. R. Lizza, G. Moura-Letts, B. D. Ficher, T. M. Keck
This study evaluates the analgesic, rewarding, and discriminative stimulus properties of IBNtxA, finding it produces potent antinociception with low abuse liability due to κ agonist effects.
bioRxiv · May 30, 2020Pharmacology & Toxicology