The CB1 Negative Allosteric Modulator PSNCBAM-1 Reduces Ethanol Self-Administration via a Nonspecific Hypophagic Effect
H. M. Buechler, M. Sumi, I. M. Madhurathakam, C. Donegan, F. DiGiorgio, A. Acosta, S. Uribe, M. A. Rahman, A. Sorbello, B. D. Fischer, T. M. Keck
This study evaluates PSNCBAM-1, a CB1 negative allosteric modulator, in rodent models of AUD and finds it reduces ethanol self-administration via a nonspecific hypophagic effect without affecting ethanol reward.
bioRxiv · Jun 30, 2023Pharmacology & Toxicology