Primary cilia loss promotes reactivation of morphogenesis and cyst-fission through a deregulated TGFβ-ECM-Integrin axis in polycystic liver disease.
S. H. Waddell, Y. Yao, P. Olaizola, E. J. Jarman, K. Gournopanos, E. Christodoulou, P. Gautier, J. P. Drenth, T. J. Kendall, J. M. Banales, A. Khamseh, P. Mill, L. Boulter
The paper shows that loss of primary cilia in adult mouse bile duct cells leads to cyst formation via a fibronectin-rich microenvironment and a novel cyst-fission process, which can be inhibited by targeting a specific integrin receptor.
bioRxiv · Apr 8, 2022 · PreprintCell Biology