Author

A. Ewing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Assay:whole-genome sequencing· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Research Focus:variant calling· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. A. Semple· 4 shared A. Meynert· 3 shared A. Matakidou· 2 shared A. V. Biankin· 2 shared B. Dougherty· 2 shared B. McDade· 2 shared C. Bartos· 2 shared C. Gourley· 2 shared

Activity by Year

2019-2024 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

C. A. Semple

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5 papers

Recent·Most cited

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

A. Ewing, A. Meynert, R. Silk, S. Aitken, D. P. Bendixsen, M. Churchman, S. L. Brown, A. Hamdan, J. Mattocks, G. R. Grimes, T. Ballinger, R. L. Hollis, C. S. Herrington, J. P. Thomson, K. Sherwood, , C. A. Semple

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

bioRxiv · Jan 12, 2024Cancer Biology

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

A. Krishna, A. Meynert, M. Kelder, A. Ewing, S. Sheraz, A. Ferrer-Vacquer, G. Grimes, H. Becher, R. Silk, C. A. Semple, T. Kendall, A.-K. Hadjantonakis, T. Bird, J. A. Marsh, P. Hohenstein, , D. D. Ozdemir

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

bioRxiv · Nov 9, 2023 · PreprintCancer Biology

Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

A. Ewing, A. Meynert, M. Churchman, G. R. Grimes, R. L. Hollis, C. S. Herrington, T. Rye, C. Bartos, I. Croy, M. Ferguson, M. Lennie, T. McGoldrick, N. McPhail, N. Siddiqui, S. Dowson, , C. A. Semple

This study identifies large structural variants as a significant source of homologous repair deficiency in high-grade serous ovarian carcinoma, beyond known SNVs and indels at BRCA1/2.

bioRxiv · May 11, 2020Cancer Biology

Pervasive lesion segregation shapes cancer genome evolution

S. J. Aitken, C. J. Anderson, F. Connor, O. Pich, V. Sundaram, C. Feig, T. F. Rayner, M. Lukk, S. Aitken, J. Luft, E. Kentepozidou, C. Arnedo-Pac, S. Beentjes, S. E. Davies, R. M. Drews, , M. S. Taylor

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

bioRxiv · Dec 8, 2019Cancer Biology

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

A. von Kriegsheim, A. Bolado-Carrancio, M. Muir, A. Ewing, K. Macleod, W. Gallagher, L. Nguyen, N. O. Carragher, C. Semple, V. Brunton, P. Caswell

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

bioRxiv · Sep 12, 2019Cancer Biology