Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo
R. M. Linville, A. Komin, X. Lan, J. G. DeStefano, C. Chu, G. Liu, P. Walczak, K. Hristova, P. C. Searson
This study demonstrates that melittin, a bee venom peptide, can reversibly open the blood-brain barrier in vitro and in vivo, enabling therapeutic delivery while maintaining neurological safety.
bioRxiv · Feb 9, 2021Bioengineering