C. Chu

Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

This study uses single-cell RNA sequencing to identify unique cell clusters and immunosuppressive features in cervical adenocarcinoma compared to squamous cell carcinoma.

An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling

This study shows that a CILK1 variant linked to epilepsy impairs primary cilia and Hedgehog signaling by disrupting KATNIP regulation in mouse cells.

Capturing G protein-coupled receptors into native lipid-bilayer nanodiscs using new diisobutylene/maleic acid (DIBMA) copolymers

This paper introduces new DIBMA-based copolymers for extracting GPCRs into native lipid-bilayer nanodiscs, showing improved performance over existing polymers like SMA.

Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals.

The paper identifies senescent SPP1+ macrophages as inhibitors of immune response and tissue repair in aged mice using ECM scaffolds.

Climate change decreases the likelihood of tropical forest community persistence with a strong mediation of plant-plant network structures

The paper assesses how climate change affects tropical forest community persistence by analyzing plant-plant interaction networks and structural stability over 25 years.

Forest demography and biomass accumulation rates are associated with transient mean tree size vs density scaling relations

The paper links mean tree size and density scaling relationships to biomass accumulation rates and demographic processes across forest biomes.

A gel-coated air-liquid-interface culture system with tunable substrate stiffness matching healthy and diseased lung tissues

This paper introduces a gel-coated air-liquid-interface culture system that mimics the stiffness of healthy and fibrotic lung tissues, showing enhanced cell migration on pathological stiffness.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription

This study quantifies LINE-1 retrotransposition and expression in cancer, showing TP53 mutations enable retrotransposition by disinhibiting L1 expression and enabling reintegration.

A novel method revealing animal evolutionary relationships based on milk Mid-infrared

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

Statistical modelling of aquatic size spectra: integrating data from multiple taxa and sampling methods

This paper develops a statistical model to integrate size spectra data from multiple taxa and sampling methods, showing that combining data improves spectrum estimation and reveals between-group trophic heterogeneity.

Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5

This study identifies TERT's non-canonical role in osteogenic reprogramming of aortic valve cells through STAT5, offering a potential therapeutic target for calcific aortic valve disease.

A latitudinal pattern of plant leaf-associated bacterial community assembly

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

Spatial anchor of adaptive immune cell around biomaterials mediated large-scale wound regeneration

This study shows that adaptive immune cells around biomaterials promote hair follicle regeneration by activating fibroblasts, highlighting their role in wound healing.

Genetic Variation and Disease Severity of Respiratory Syncytial Viruses

This study investigates the association between RSV genetic variations and disease severity in infants, finding significant links between phylogeny and specific protein variations in different subtypes.

Disentangling key species interactions in diverse and heterogeneous communities: A Bayesian sparse modeling approach

This paper introduces a Bayesian sparse modeling approach to identify key species interactions in diverse communities by reducing parameter complexity and distinguishing environmental effects from competitive interactions.

The Diameter Factor of Aligned Electrospinning Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization

This study shows that aligned electrospinning membranes with 319 nm diameter enhance skin wound healing by promoting epithelialization and macrophage transformation through IL10 and TGFβ expression.

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo

This study demonstrates that melittin, a bee venom peptide, can reversibly open the blood-brain barrier in vitro and in vivo, enabling therapeutic delivery while maintaining neurological safety.

Application of EGCG modified EDC/NHS cross-linked extracellular matrix to promote macrophage adhesion

The paper develops an EGCG-modified EDC/NHS collagen membrane to enhance macrophage adhesion and vascularization, showing improved cell viability and potential for implant dentistry.

Consideration of macrophage phenotypes under biomaterials mediated host defense process

The paper shows that screening macrophages before analysis is crucial for accurate phenotype identification and that CAMP expression does not fit traditional M1/M2 classification.

Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.

Cell-free DNA as a biomarker for prostate cancer: elevated concentration and decreased fragment size

This study finds that higher plasma cfDNA concentrations and smaller fragment sizes are associated with more advanced prostate cancer.

Species packing and the latitudinal gradient in beta-diversity

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

ARG1 could be expressed by human, but not represent for repair

This study investigates whether ARG1 is expressed during human bone healing and finds it is not a reliable marker for regeneration.

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

CLADES: A Classification-based Machine Learning Method for Species Delimitation from Population Genetic Data

CLADES uses machine learning to delimit species from population genetic data, showing accuracy and efficiency compared to existing methods, especially in cases with short divergence times and gene flow.