G. Liu

Epithelial miR-149-5p up-regulation is associated with immune evasion in progressive bronchial premalignant lesions

This study identifies hsa-miR-149-5p as a regulator of immune evasion in progressive bronchial premalignant lesions through integrative analysis of RNA and miRNA sequencing data.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

TPM4 condensates glycolytic enzymes to fuel actin reorganization under hyperosmotic stress

The paper shows that TPM4 forms condensates with glycolytic enzymes under hyperosmotic stress, linking actin reorganization to metabolic activity.

A combinatorially complete epistatic fitness landscape in an enzyme active site

The paper constructs a large-scale sequence-fitness dataset for enzyme engineering, revealing significant epistasis and highlighting challenges in predicting optimal variants.

Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics

ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis

This study identifies ISGylation of SARS-CoV-2 N protein by HERC5 as a host restriction factor that inhibits viral RNA synthesis by blocking N oligomerization.

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

Pools of independently cycling inositol phosphates revealed by pulse labeling with 18O-water

The paper uses 18O-water labeling to study phosphate group dynamics in inositol phosphates across species, revealing distinct pools with different cycling behaviors.

The enhancement of electricity generation using cellulose based on ternary microbial consortium

This paper demonstrates that a ternary microbial consortium enhances electricity generation from cellulose by synergistically converting it to acetate and using riboflavin as an electron shuttle.

HOIL1 mediates MDA5 activation through ubiquitination of LGP2

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

Structural insights into physiological activation and antagonism of melanin-concentrating hormone receptor MCHR1

This study presents cryo-EM structures of MCHR1 in active and inactive states, revealing ligand recognition and activation mechanisms to aid drug development.

Aerobic exercise promotes PDAC vascular normalization through S1PR1 signaling in tumor endothelial cells

This study shows aerobic exercise improves PDAC vascular function and chemotherapy efficacy via S1PR1 signaling in tumor endothelial cells.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

Perinatal ampicillin administration modulates murine bile acid metabolism in vivo - an observational study

This study examines how ampicillin exposure via different routes affects bile acid metabolism in mice, finding significant changes in maternal bile acids and increased infant weight.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

Torques within and outside the human spindle balance twist at anaphase

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

Conservation of heat stress acclimation by the inositol polyphosphate multikinase, IPMK responsible for 4/6-InsP7 production in land plants

This study identifies IPMK as the enzyme responsible for producing 4/6-InsP7 in land plants and shows its role in heat stress acclimation through regulation of HSF transcription activity.

Multi-Factor Coral Disease Risk Forecasting for Early Warning and Management

This paper develops a coral disease risk forecasting system using ecological and environmental data to predict disease risk in coral reefs, showing improved accuracy compared to previous systems.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

Biodegradable hyperbranched poly(amine-co-ester)-based polymeric nanoparticles for mRNA delivery

This study develops a biodegradable hyperbranched poly(amine-co-ester) nanoparticle for efficient and safe mRNA delivery, showing improved performance over existing commercial reagents.

Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

Epidermal Growth Factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

The paper shows EGF enhances TNBC cells' response to CAP-activated medium by activating specific EGFR phospho-tyrosines and increasing ROS levels.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

Characterization, Comparison, and Optimization of Lattice Light Sheets

This paper compares and optimizes lattice light sheets to improve resolution and reduce photobleaching in light sheet microscopy.

Nightmare or delight: taxonomic circumscription meets reticulate evolution in the phylogenomic era

The paper investigates reticulate evolution in the genus Stranvaesia using phylogenomic data, revealing how hybridization and allopolyploidy influence taxonomic classification and leading to the description of a new genus.