X. Lan

An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling

The paper introduces an unbiased proteomic platform for ATE1-based arginylation profiling, identifying 235 unique arginylation sites in human proteomes.

Microbial single-cell omics in situ

The paper reports a method using LIFT technology to obtain high-quality microbial single-cell genomes or transcriptomes from complex samples and demonstrates its application to study cell-fate commitment in sporulation.

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

Hypoxia impacts small intestinal organoid stemness and differentiation

This study shows that hypoxia increases secretory cells and decreases absorptive cells in mouse small intestinal organoids, impacting stem cell numbers and epithelial regeneration.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Disabling of ARC1 through CRISPR/CAS9 leads to a complete breakdown of self-incompatibility responses in Brassica napus

This study shows that disabling ARC1 via CRISPR/Cas9 in Brassica napus completely breaks down self-incompatibility responses in two S-haplotypes.

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

Screening of Botanical Drugs against SARS-CoV-2 Entry

This study screens botanical drugs against SARS-CoV-2 entry and identifies four compounds that inhibit viral entry and show synergy with remdesivir.

Reversible blood-brain barrier opening utilizing the membrane active peptide melittin in vitro and in vivo

This study demonstrates that melittin, a bee venom peptide, can reversibly open the blood-brain barrier in vitro and in vivo, enabling therapeutic delivery while maintaining neurological safety.

RNAi screening reveals requirement for PDGFRβ in JEV infection.

This study identifies PDGFRβ as a host factor required for JEV infection and shows that imatinib can protect against JEV by reducing viral load and histopathology.

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

This study characterizes an adaptive mutant of Lassa virus glycoprotein complex that confers resistance to fusion inhibitors and alters viral fusion properties.

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

An evolutionary switch in the specificity of an endosomal CORVET tether underlies formation of regulated secretory vesicles in the ciliate Tetrahymena thermophila

The paper identifies an evolutionary switch in the specificity of a CORVET tether in Tetrahymena thermophila that enables the formation of regulated secretory vesicles called mucocysts.