Author

A. Kunka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Bednar· 2 shared J. Damborsky· 2 shared S. Mazurenko· 2 shared Z. Prokop· 2 shared A. Legrand· 1 shared D. Horak· 1 shared E. Sebestova· 1 shared J. Brezovky· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

D. Bednar

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

CoVAMPnet: Comparative Markov State Analysis for Studying Effects of Drug Candidates on Disordered Biomolecules

S. M. Marques, P. Kouba, A. Legrand, J. Sedlar, L. Disson, J. Planas-Iglesias, Z. Sanusi, A. Kunka, J. Damborsky, T. Pajdla, Z. Prokop, S. Mazurenko, J. Sivic, D. Bednar

This paper introduces CoVAMPnet, a framework to analyze how drug candidates affect disordered biomolecules, finding that TMP and SPA preserve structured conformations of Aβ42.

bioRxiv · Jan 6, 2023Biophysics

Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2

P. Dvorak, D. Bednar, P. Vanacek, L. Balek, L. Eiselleova, V. Stepankova, E. Sebestova, M. Kunova Bosakova, Z. Konecna, S. Mazurenko, A. Kunka, D. Horak, R. Chaloupkova, J. Brezovky, P. Krejci, , J. Damborsky

This paper describes the engineering of a hyperstable FGF2 variant with nine mutations using a computer-assisted strategy, achieving high stability without losing biological function.

bioRxiv · Jan 15, 2017Bioengineering