Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2TG Mice
R. Roytenberg, H. Yue, A. DeHart, E. Kim, F. Bai, Y. Kim, K. Denning, A. Kwei, Q. Zhang, J. Liu, L. Zheng, W. Li
This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.
bioRxiv · Feb 23, 2024 · PreprintCell Biology