Y. Kim

Microbiome-Targeted Reduction of Circulating Trimethylamine N-Oxide Mitigates Ischemic Stroke Risk

This study identifies Paracoccus aminovorans BM109 as a microbiome-targeted therapy that reduces TMAO levels and mitigates ischemic stroke risk in animal models.

A forward-engineered muscle tissue driven soft robotic swimmer

The paper builds a biohybrid robot with muscle-driven tail motion to study swimming dynamics and muscle adaptation, achieving speeds surpassing low-Reynolds number predictions.

Nitrous oxide respiration in acidophilic methanotrophs

This study shows that two acidophilic methanotrophs can respire N2O and grow anaerobically, expanding their ecological niche and offering potential for greenhouse gas mitigation.

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

This study identifies PHGDH induction via MAPK and mTORC1 pathways as essential for melanoma formation and shows that combining BRAFV600E inhibition with serine restriction can target this vulnerability.

An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

This study uses engineered human cardiac tissues to show how SLE autoantibodies affect myocardial injury through distinct binding patterns and functional effects on cardiac cells.

The effect of enriched versus inadequate housing conditions on eucalyptus smoke-induced cardiovascular dysfunction in mice

This study shows that enriched housing improves cardiopulmonary resilience to wildfire smoke in mice compared to depleted housing.

Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2TG Mice

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Time resolved multi-omics reveals diverse metabolic strategies of Salmonella during diet-induced inflammation

This study uses multi-omics to analyze Salmonella's metabolic strategies in mice on different diets over time, identifying phase-specific gene expression linked to infection stages and therapeutic targets.

Mitotic waves in frog egg extracts: Transition from phase waves to trigger waves

The paper observes a transition from phase waves to trigger waves in Xenopus egg extracts and shows how these waves coordinate the cell cycle over long distances.

Impact of Capillary and Sarcolemmal Proximity on Mitochondrial Structure and Energetic Function in Skeletal Muscle

The paper compares mitochondrial structure and function in skeletal muscle based on proximity to capillaries or sarcolemma, finding capillary proximity enhances energy conversion and distribution.

Development of novel high-resolution melting markers for the assessment of hybridization between Mauremys sinensis and Mauremys reevesii in South Korea

This study develops high-resolution melting markers to detect hybridization between Mauremys sinensis and Mauremys reevesii in South Korea, identifying hybrid individuals at multiple sites.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

This study introduces SynPrime, a prime editing-based method to evaluate EGFR variant resistance to TKIs, identifying functional effects of 2,476 SNVs and improving precision in therapeutic choices.

Assessing Tumor Microenvironment Characteristics and Stratifying EPR with a Nanobubble Companion Nanoparticle via Contrast-Enhanced Ultrasound Imaging

This paper uses contrast-enhanced ultrasound imaging with nanobubbles to assess tumor microenvironment characteristics and predict nanoparticle distribution in tumors with different vascular permeability.

Herbicidal Quassinoids Isolated from Ailanthus altissima Leaves

The paper isolates and characterizes quassinoids from Ailanthus altissima leaves and evaluates their herbicidal activity against various weeds.

BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia

This study identifies BHLHE40 as a key driver of polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia, showing its role in limiting bacterial shedding.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

This study uses genome editing in adult mice with a MIR96 mutation to restore hearing, showing efficacy that improves with earlier intervention.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

ASCT2 is the primary serine transporter in cancer cells

This study identifies ASCT2 as the primary serine transporter in cancer cells and shows its role in purine biosynthesis and therapeutic targeting.

Ultrasound-Mediated Drug-free Theranostics for Treatment of Prostate Cancer

This paper demonstrates that PSMA-targeted nanobubbles combined with ultrasound treatment selectively induce apoptosis in PSMA-expressing prostate cancer tumors in animal models.

Transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant

This study investigates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant, finding it to be highly immune evasive but with lower infectivity compared to other variants.

Nanoprojectile Secondary Ion Mass Spectrometry Enables Multiplexed Analysis of Individual Hepatic Extracellular Vesicles

This study uses NP-SIMS to analyze single hepatic extracellular vesicles, distinguishing between normal and cancerous EVs based on surface marker expression.

Phospholipase A2 activity is required for immune defense of European (Apis mellifera) and Asian (Apis cerana) honeybees against the American foulbrood pathogen, Paenibacillus larvae

This study shows that phospholipase A2 activity is essential for immune defense in European and Asian honeybees against Paenibacillus larvae, with PLA2A and PLA2B specifically inhibiting immune responses.

One-Step Selective Labeling of Native Cell-Surface Sialoglycans by Exogenous α2,8-Sialylation

This paper identifies a sialyltransferase for selectively labeling native cell-surface sialoglycans with 2,8-disialyl epitopes using exogenous CMP-Neu5Ac derivatives.

Structure of a tripartite protein complex that targets toxins to the type VII secretion system

The paper presents the structure of a tripartite protein complex involving LXG domains and Lap proteins, revealing a conserved mechanism for toxin export via the type VII secretion system.

Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes

The paper identifies cis-regulatory evolution in translation genes in stem cells of M. m. castaneus compared to sister taxa using expression and population-genomic data.

Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity

This study investigates the role of EpOMEs and DiHOMEs in insect immune resolution, showing EpOMEs suppress immune responses while DiHOMEs enhance antimicrobial peptide expression, and their dysregulation increases susceptibility to pathogens.