E. Kim

MagicLamp: a web server and software toolkit for targeted gene annotation of microbial functions

MagicLamp provides a toolkit and web server for targeted microbial function annotation using curated HMMs, enabling sensitive and specific gene annotation for specialized processes.

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary Cancers

The paper develops and validates a clinicogenomic risk model to predict second primary cancers in cancer survivors using genetic, clinical, and lifestyle factors.

Hidden route of protein damage through confined oxygen gas

The paper identifies a hidden oxidative damage pathway in proteins through O2 confinement and photoexcitation, bypassing antioxidant defenses.

Lipid loss and compositional change during preparation of liposomes by common biophysical methods

This paper quantifies lipid loss and compositional changes during liposome preparation using HPLC-ELSD and identifies best practices to maximize lipid recovery and minimize composition bias.

Courtship song differs between African and European populations of Drosophila melanogaster and involves a strong effect locus

The paper identifies a strong genetic locus influencing courtship song differences between African and European Drosophila melanogaster populations.

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions

This study shows that PV antibodies cause tension loss at desmosomes and cell-cell adhesions by inhibiting RhoA, which can be partially reversed by altering actomyosin contractility.

Loss of Paneth cells dysregulates gut ILC subsets and enhances weight gain response to high fat diet in a mouse model.

The paper shows that loss of Paneth cells in mice alters gut ILC subsets and increases weight gain on a high-fat diet.

Molecular Mechanism of Condensin I Activation by KIF4A

The paper identifies a conserved mechanism by which KIF4A activates condensin I through direct binding to NCAPG and displacement of auto-inhibitory interactions.

Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure in Enterobacter cloacae

This study identifies three genetic factors in Enterobacter cloacae that collectively contribute to resistance against the antimicrobial peptide cecropin B, showing inoculum-dependent survival heterogeneity.

Thymidine Phosphorylase Mediates SARS-CoV-2 Spike Protein Enhanced Thrombosis in K18-hACE2TG Mice

This study identifies thymidine phosphorylase (TYMP) as a mediator of SARS-CoV-2 spike protein-induced thrombosis in mice, showing that TYMP inhibition reduces thrombosis and coagulation.

Second Boost of Omicron SARS-CoV-2 S1 Subunit Vaccine Induced Broad Humoral Immune Responses in Elderly Mice

This study shows that a second booster dose of an Omicron S1 subunit vaccine enhances broad humoral immunity and cross-neutralizing antibodies in elderly mice.

A gene-rich mitochondrion with a unique ancestral protein transport system

This paper describes the mitogenome of Mantamonas sphyraenae, which has the most gene-rich mitochondrial genome outside of jakobids, encoding a complete mitochondrial Sec translocation system.

Cannabis sativa (Hemp) seed-derived peptides WVYY and PSLPA modulate the Nrf2 signaling pathway in human keratinocytes

This study investigates the antioxidant and antibacterial effects of hemp seed-derived peptides WVYY and PSLPA, showing their activation of the Nrf2 signaling pathway in human keratinocytes.

Song Torrent: A modular, open-source 96-chamber audio and video recording apparatus with optogenetic activation and inactivation capabilities for Drosophila

The paper describes a modular, open-source system for high-throughput audio and video recording of Drosophila courtship behavior with optogenetic capabilities.

Spatial characterization of interface dermatitis in cutaneous lupus reveals novel chemokine ligand-receptor pairs that drive disease

This study identifies novel chemokine ligand-receptor pairs involved in immune cell recruitment in cutaneous lupus by combining spatial transcriptomics, proteomics, and immunological assays.

Detecting Features of Protein Structure through their Mediator-Accessible Redox Activities

This paper introduces an electronic detection method to identify structural perturbations in proteins by measuring mediator-accessible redox activities, demonstrating its application in biomanufacturing.

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Encyclopaedia of family A DNA polymerases localized in organelles: Contribution of genes from bacteria including the proto-mitochondrion.

This study identifies and classifies 134 family A DNA polymerase sequences from diverse eukaryotes, revealing their evolutionary origins and suggesting the last eukaryotic common ancestor had two mitochondrial DNAPs.

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

Molecular and morphological characterisation of four new ancyromonad genera and proposal for an updated taxonomy of the Ancyromonadida

The paper characterizes four new ancyromonad genera and updates their taxonomy using morphology, behavior, and molecular phylogenetic analyses.

Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers

This study evaluates a tetravalent SARS-CoV-2 S1 subunit vaccine in SIV-infected rhesus macaques, showing robust humoral and cellular immune responses, including cross-reactivity against Omicron.

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa

The paper identifies tertiary lymphoid structures in HS lesions and shows B cell maturation and interactions with T cells and stroma.

Trivalent SARS-CoV-2 S1 Subunit Protein Vaccination Induces Broad Humoral Responses in BALB/c Mice

This study evaluates trivalent SARS-CoV-2 S1 subunit vaccines in mice, showing broader humoral responses and improved coverage against variants compared to monovalent vaccines.

IMPASTO: Multiplexed cyclic imaging without signal removal via self-supervised neural unmixing

IMPASTO enables erasureless cyclic imaging for multiplexed spatial proteomics through self-supervised neural unmixing, achieving 30-plex imaging with reduced tissue distortion.

Expanding the molecular and morphological diversity of Apusomonadida, a deep-branching group of gliding bacterivorous protists

The paper describes new apusomonad species and genera, updates their taxonomy, and provides insights into their evolutionary history and morphology.

The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers

This paper reports the structure and function of the photosystem I supercomplex in Ostreococcus tauri, showing it assembles with light-harvesting complexes and exhibits reversible photoacclimation.

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

This study shows that a S1 subunit booster vaccine enhances neutralizing antibodies and cross-reactivity against multiple SARS-CoV-2 variants in aged mice vaccinated with an adenovirus-based vaccine.

Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration

This paper introduces a 3D lung tumor on chip model with endothelium to evaluate T-cell infiltration modulators and demonstrates its utility in assessing immune chemotaxis and vascular responses.