Author

A. L. Burrell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. M. Kollman· 4 shared A. G. O'Neill· 2 shared J. Quispe· 2 shared J. R. Peterson· 2 shared M. C. Johnson· 2 shared R. M. Buey· 2 shared A. Andrews· 1 shared A. L. Rippert· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

J. M. Kollman

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4 papers

Recent·Most cited

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants

S. J. Calise, A. G. O'Neill, A. L. Burrell, M. S. Dickinson, J. Molfino, C. Clarke, J. Quispe, D. Sokolov, R. M. Buey, J. M. Kollman

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

bioRxiv · Sep 21, 2023Biochemistry

Point mutations in IMPDH2 which cause early-onset neurodevelopmental disorders disrupt enzyme regulation and filament structure

A. G. O'Neill, A. L. Burrell, M. Zech, O. Elpeleg, T. Harel, S. Edvardson, H. M. Shaked, A. L. Rippert, T. Nomakuchi, K. Izumi, J. M. Kollman

The paper identifies two new IMPDH2 mutations linked to neurodevelopmental disorders and shows they disrupt GTP regulation and enzyme function through structural and functional analysis.

bioRxiv · Mar 15, 2023Biochemistry

IMPDH1 retinal variants control filament architecture to tune allosteric regulation

A. L. BURRELL, C. Nie, M. Said, J. C. Simonet, D. Fernandez-Justel, M. C. Johnson, J. Quispe, R. M. Buey, J. R. Peterson, J. M. Kollman

The paper shows IMPDH1 retinal variants form different filaments that affect GTP regulation, with disease mutations disrupting or not affecting this regulation.

bioRxiv · Aug 3, 2021Biochemistry

IMPDH polymers accommodate both catalytically active and inactive conformations

S. Anthony, A. L. Burrell, M. C. Johnson, K. C. Duong-Ly, K. Yin-Ming, P. Michener, A. Andrews, J. M. Kollman, J. R. Peterson

The paper investigates IMPDH polymerization and finds that polymerized and non-assembled forms have comparable catalytic activity, with substrate and nucleotide availability affecting filament conformation.

bioRxiv · Jun 19, 2017Biochemistry