M. S. Dickinson

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.

This paper determines the structure and dynamics of the mycobacterial polyketide synthase Pks13 using cryoEM and complementary techniques, revealing intermediate states and substrate binding.

This paper identifies a hyperexcitable variant of the TPC1 channel in Vicia faba, showing it differs from Arabidopsis in Ca2+ sensitivity and vacuole excitability.

The paper determines the structure of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana and shows it undergoes symmetry reduction to regulate electrical activation.

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

This study uses proximity-dependent biotinylation to identify inclusion membrane proteins of Chlamydia trachomatis and reveals a novel interaction with endoplasmic reticulum exit sites.