C. Clarke

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

Understanding the transcriptional response to ER stress in Chinese hamster ovary cells using multiplexed single cell RNA-seq

This paper uses multiplexed scRNA-seq to study the transcriptional response of CHO cells to tunicamycin treatment and identifies gene modules associated with ER stress.

Tracing production instability in a clonally-derived CHO cell line using single cell transcriptomics

The paper uses single-cell RNA-seq to analyze production instability in a clonally-derived CHO cell line, identifying transcriptional changes and oxidative stress responses during mAb production decline.

HybPhaser: a workflow for the detection and phasing of hybrids in target capture datasets

HybPhaser detects and phases hybrids in target capture datasets by analyzing heterozygous sites and mapping reads to multiple references, improving phylogenetic accuracy.

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

This study shows that reducing temperature induces widespread alternative splicing in CHO cells, with many events occurring in genes not detected by standard expression analysis.

Expanding the Chinese hamster ovary cell long non-coding RNA transcriptome using RNASeq

This study expands the long non-coding RNA (lncRNA) transcriptome of Chinese hamster ovary (CHO) cells using RNASeq, doubling annotated lncRNA transcripts and identifying 1,000 new antisense lncRNAs.

Porous upconversion nanostructures as bimodal biomedical imaging contrast agents

This study designs core-porous shell upconversion nanoparticles to enhance both fluorescent and MRI signals for dual-modal biomedical imaging.