Site-specific effects of neurosteroids on GABAA receptor activation and desensitization
Y. Sugasawa, W. W. Cheng, J. Bracamontes, Z.-W. Chen, L. Wang, A. L. Germann, S. R. Pierce, T. C. Senneff, K. Krishnan, D. E. Reichert, D. F. Covey, G. Akk, A. Evers
This study identifies how neurosteroids interact with three distinct sites on the GABAA receptor, influencing activation and desensitization, and shows that site-specific binding determines their functional effects.
bioRxiv · Apr 27, 2020Biophysics