S. Lim

Eyes on VR: Unpacking the Causal Chain Between Exposure, Reception, and Retention for Emotional Billboard Messages

This study uses VR to examine how exposure, reception, and retention of emotional billboard messages are interconnected, finding exposure gates effects, distraction influences exposure, and emotional content and distraction affect retention.

Modulation of Ideonella sakaiensis PETase active site flexibility and activity on morphologically distinct substrates by surface charge engineering

The paper investigates how surface charge mutations affect PETase activity on different PET substrates and identifies an engineered variant with improved degradation efficiency.

Characterization of the murine spine for spaceflight studies

This study examines the effects of 28 days of spaceflight on the murine lumbar spine and proximal tibia, finding no significant changes in vertebral bone microarchitecture or intervertebral disc properties, but significant bone loss in the tibia.

The eyes have it: Inter-subject correlations of pupillary responses for audience response measurement in VR

This paper introduces a VR-based method to measure audience responses through pupillary responses and shows it can accurately decode video identity and memory.

Slow conduction and spatial dispersion of repolarization are intrinsic properties of cardiomyocyte electrophysiology that contribute to proarrhythmia in an iPSC model of hypertrophic cardiomyopathy

This study shows that HCM cardiomyocytes have slower conduction and increased repolarization dispersion, which contribute to arrhythmia in an iPSC model.

Modeling the seasonal variation of windborne transmission of porcine reproductive and respiratory syndrome virus between swine farms

The paper models seasonal windborne transmission of PRRSv between swine farms using HYSPLIT, finding higher risk in winter and fall due to virus survival and long-distance spread.

The VR Billboard Paradigm: Using VR and Eye-tracking to Examine the Exposure-Reception-Retention Link in Realistic Communication Environments

This paper uses VR and eye-tracking to measure exposure, reception, and retention of messages in realistic environments, showing that attention manipulation affects gaze and memory.

A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle

This paper reveals the ATP-driven structural rearrangement of PhLP2A during TRiC-mediated protein folding using cryoEM and biochemical analyses.

Comparison of commercial DNA extraction kits for whole metagenome sequencing of human oral, vaginal, and rectal microbiome samples

This study compares four DNA extraction kits for whole metagenome sequencing of human oral, vaginal, and rectal microbiome samples, finding systematic biases in microbial taxa representation.

Back to the Future: Unleashing your cytometers spectral potential

This paper demonstrates that traditional flow cytometers can be used as spectral cytometers by unmixing data acquired from them.

High spontaneous integration rates of end-modified linear DNAs upon mammalian cell transfection

This study compares genomic integration rates of different DNA forms in mammalian cells, finding that end-modified linear DNAs still integrate at high rates.

Large-scale duplication events underpin population-level flexibility in tRNA gene copy number in Pseudomonas fluorescens SBW25

The paper shows that Pseudomonas fluorescens SBW25 can rapidly generate tRNA gene set diversity through unstable large-scale duplications, which can preserve or alter tRNA gene copy numbers depending on selection pressure.

Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism

This study investigates how His-rich peptide coacervates enter cells, finding they use a macropinocytosis-like mechanism involving cytoskeleton rearrangement and filopodia capture.

Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export

This study shows Sus1 regulates yeast lifespan by linking transcription to mRNA export through the TREX-2 complex, with mRNA export factors rescuing lifespan defects in sus1 mutants.

Amplification of Olfactory Signals by Anoctamin 9 is Essential for Mammalian Olfaction: a Risk Factor for the Covid-19-associated Anosmia

This study identifies Anoctamin 9 as essential for mammalian olfaction, showing its role in amplifying olfactory signals and linking its downregulation to Covid-19-associated anosmia.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

This study shows that targeted degradation of PCNA via biodegraders leads to more effective anti-proliferative effects and programmed cell death compared to stoichiometric inhibition.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

Formation, collective motion, and merging of macroscopicbacterial aggregates

This study examines the formation and dynamics of bacterial aggregates in Enterobacter cloacae, revealing a new mechanism of collective motility driven by density-dependent motility changes.

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

STUB1 is an intracellular checkpoint for interferon gamma sensing

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

Newly developed silicone airway stent (GINA stent): Mechanical characteristics and performance evaluation in pigs

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

bioPROTACs establish RAS as a degradable target and provide novel RAS biology insights

The paper demonstrates that RAS proteins can be degraded using bioPROTACs and provides insights into the functional consequences of RAS degradation and mutant susceptibility.

Synergistic epistasis enhances cooperativity of mutualistic interspecies interactions

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

Direct RNA sequencing reveals structural differences between transcript isoforms

This study introduces PORE-cupine, a method combining structure probing and nanopore sequencing to detect RNA secondary structures, revealing isoform-specific structural differences and their impact on translation efficiency.

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

Conjugates of neuroprotective chaperone L-PGDS provide MRI contrast for detection of amyloid β-rich regions in live Alzheimer's Disease mouse model brain

This study conjugates the neuroprotective chaperone L-PGDS with magnetic nanoparticles to enhance MRI contrast for detecting amyloid β-rich regions in Alzheimer's Disease mouse models.

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)

This paper introduces bioPROTACs as intracellular biologics for targeted protein degradation, demonstrating their effectiveness against PCNA with rapid degradation and functional effects.