PhysiologybioRxiv
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
R. K. Powers, K. D. Sullivan, R. Culp-Hill…·J. M. Espinosa
This study identifies a mechanism by which Trisomy 21 increases kynurenine pathway activity through overexpression of interferon receptors, leading to immunosuppression and neurotoxicity in Down syndrome.
DOI 10.1038/s41467-019-12739-9